The phone comes with a 6.4-inch touchscreen display. Samsung Galaxy S21 FE 5G is powered by an octa-core processor. It comes with 8GB of RAM. The Samsung Galaxy S21 FE 5G runs Android 12 and is powered by a 4500mAh battery. The Samsung Galaxy S21 FE 5G supports wireless charging, as well as proprietary fast charging.

As far as the cameras are concerned, the Samsung Galaxy S21 FE 5G on the rear packs a triple camera setup featuring a 12-megapixel primary camera with an f/1.8 aperture; a 12-megapixel camera with an f/2.2 aperture, and an 8-megapixel camera with an f/2.4 aperture. The rear camera setup has autofocus. It has a single front camera setup for selfies, featuring a 32-megapixel sensor with an f/2.2 aperture.

The Samsung Galaxy S21 FE 5G runs One UI 4 is based on Android 12 and packs 128GB of inbuilt storage. The Samsung Galaxy S21 FE 5G is a dual-SIM (GSM and GSM) mobile that accepts Nano-SIM and Nano-SIM cards. It features an IP68 rating for dust and water protection